| Sibutramine [Meridia, Reductil] is a centrally acting stimulant chemically related to amphetamines. Usually is an orally administered agent for the treatment of obesity. |
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| Sibutramine is well absorbed from the GI tract (77%), but undergoes considerable first-pass metabolism reducing its bioavailability. | |
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| 10 mg once daily (in the morning), if this proves insufficient the dose may be increased to 15 mg daily after 4 weeks. | |
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